The surface of the Sartopore Platinum polyethersulphone filter membrane has been modified using a hydrophilic and highly thermostable polymer. This surface modification gives the membrane good wetting properties and minimises its protein binding. Fewer than five litres of WFI (Water for Injection) are needed to wet a 10 inch Sartopore Platinum cartridge fast and reliably for subsequent integrity testing that provides dependably accurate results.According to Sartorius Stedim Biotech (SSB), the membrane’s minimised protein binding considerably increases product yield, thus augmenting the efficiency of manufacturing processes. Sartopore Platinum filter cartridges can be dry-steam sterilised in the forward or the reverse direction, without altering the properties of their membrane. These sterilising-grade filters can be used in the entire pH range from 1 to 14 and thus for nearly any filtration application in biopharmaceutical manufacturing.The membrane of the Sartopore Platinum filter cartridges has been pleated using SSB’s newly developed, proprietary TwinPleat® process. The alternating long and short pleats of the membrane increase the filter area of a 10 inch cartridge by more than 60 percent. At the same time, this geometry ensures that liquids flow through the entire filter area so that the filtration capacity of the cartridge is used to the fullest extent. As a result, Sartopore Platinum filter cartridges substantially boost filtration performance and lower filtration costs.The new sterilising-grade filter cartridges are available in a choice of different sizes and constructions ranging from laboratory to production scale. In all sizes, identical materials of construction with consistent performance characteristics are used. Therefore, Sartopore Platinum enables linear scale-up for a large number of applications in the biopharmaceutical industry.