The resin has been developed as part of GE Healthcare’s Custom Designed Media (CDM) programme and provides a new solution for AAT purification in the biopharmaceutical industry.
AAT deficiency is a common genetic disorder thought to affect approximately 200,000 people in North America and Europe. AAT is a protease inhibitor that protects body fluids and tissues from the body’s own protease enzymes, and a deficiency can lead to emphysema, COPD, or in some cases, liver damage. AAT deficiency can be treated by supplementing patients’ AAT levels.
Henrik Ihre, director of Custom Designed Media at GE Healthcare said: “Combining BAC’s know-how in innovative affinity ligand technology with GE Healthcare’s downstream processing expertise, enables us to supply our customers with tailored chromatography media for their specific purification needs. This opens the door for more cost-efficient production of many biotherapeutics, such as AAT.”