Thermo Fisher Scientific will launch its next generation of ultra-high performance liquid chromatography (UHPLC) systems at Analytica 2018. Developed in response to the analytical complexity of new and emerging pharmaceuticals and biopharmaceuticals, the Vanquish Duo UHPLC systems are designed to maximize throughput and return on investment (ROI). 

"The increasing demand being placed on the pharmaceutical and biopharmaceutical industry to deliver safe and effective medicines that meet regulatory standards is presenting a unique set of analytical challenges," says Fabrizio Moltoni, vice president and general manager, HPLC, chromatography and mass spectrometry, Thermo Fisher Scientific. "The Vanquish Duo UHPLC systems provide a high-throughput and robust solution required to enable full characterization of small and large molecules in a manner that creates confidence and quality, while helping to protect customers’ investment."

Each system in the Vanquish Duo UHPLC family tackles different analytical challenges. The Vanquish Duo for Dual LC system runs two applications in parallel on a single instrument – whether used for identical analysis to double throughput or for different analysis for deeper sample knowledge. The system can increase capacity and performance without sacrificing bench space. The Vanquish Duo for Tandem LC or LC-MS system is designed to provide maximum sample throughput and positive ROI by eliminating column reconditioning to maximize detector/mass spectrometer utilization. The system splits the analysis between two pumps, delivering a configuration that allows two identical columns to be run sequentially. One pump delivers the analytical gradient while the second pump delivers the recondition gradient intended to provide faster analysis without compromising data quality. The Vanquish Duo for Inverse Gradient enhances detection for Thermo Fisher’s charged aerosol detection (CAD) technology. The inverse gradient is formulated to provide a uniform CAD response under gradient elution conditions – allowing users to reliably quantify the compounds in a sample without bias.

The analytical power of the Vanquish Duo UHPLC systems is maximized through integration with Thermo Scientific Chromeleon Chromatography Data System (CDS) software.