The 3M Emphaze AEX Hybrid Purifier, the first in a series of chromatography and membrane chromatographic products, features polymer materials, fine fibre nonwovens, and contains both a novel anion exchange nonwoven media, and a fine particle, bioburden reduction membrane. The 3M Emphaze AEX hybrid purifier laboratory and scale-up capsules are now available with the production capsules to be launched at the end of the year. They are suitable for biopharmaceutical manufacturing.
“The 3M Emphaze AEX Hybrid Purifier is a multi-mechanism clarifying device,” said Tom Martin, global business manager, life sciences process technologies, 3M Purification. “This product actually represents a new class of clarifying products, with an all-synthetic construction, substantial chromatographic capability, and a defined 0.2 μm pore size.”
The defined pore size of the qualifying membrane provides removal of insoluble particles below 0.1 µm in size, resulting in improved turbidity reduction, while the Q-functional nonwoven can reduce negatively charged, soluble impurities including DNA and HCP. The hybrid purifier can provide superior product purity before and after the protein A column.
The 3M Emphaze AEX Hybrid Purifier offers a loading capacity similar to fine grades of highly-charged conventional depth filters, and can easily be incorporated into existing manufacturing processes where such a depth filter would be used.